Catalyst Biosciences
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Publications

Selected Publications by Catalyst personnel:

Charles S Craik, PhD

  • Redesigning Trypsin: Alteration of Substrate Specificity, Catalytic Activity and Protein Conformation. C.S. Craik, C. Largman, T. Fletcher, P. Barr, R.J. Fletterick & W.J. Rutter. Science 228, 291-297 (1985)
  • The Three Dimensional Structure of Asnl02 Trypsin: Role of Aspl02 in Serine Protease Catalysis. S. Sprang, T. Standing, R.J. Fletterick, R. Stroud, J. Finer-Moore, N.-H. Xuong, R. Hamlin, W. J. Rutter & C.S. Craik. Science 237, 905-909 (1987)
  • Introduction of a Cysteine Protease Active Site into Trypsin. J. Higaki L.B. Evnin & C.S. Craik. Biochem. 28, 9256-9263 (1989)
  • Regulation of Serine Protease Activity by an Engineered Metal Switch. J.N. Higaki, B.L. Haymore, S. Chen, R.J. Fletterick & C.S. Craik. Biochem. 29, 8582-8586 (1990)
  • Relocating a Negative Charge in the Binding Pocket of Trypsin. J.J. Perona, C.A. Tsu, M.E. McGrath, C.S. Craik & R.J. Fletterick. J. Mol. Bio. 230, 934-949 (1993)
  • Structural Determinants of Specificity in the Cysteine Protease Cruzain. S.A. Gillmor, C.S. Craik & R.J. Fletterick. Protein Sci. 6, 1603-1611 (1997)
  • Evolutionary Divergence of Substrate Specificity Within the Chymotrypsin-like Serine Protease Fold. J. Perona & C.S. Craik. J. Biological Chemistry 272, 29987-29990 (1997)
  • Engineering Enzyme Specificity. J.L. Harris & C.S. Craik. Curr. Opin. Chem Bio. 2 (1), 127-132 (1998)
  • Definition and Redesign of the Extended Substrate Specificity of Granzyme B. J.L. Harris, E.P. Peterson, D. Hudig, N.A. Thornberry & C.S. Craik. J. Bio. Chem. 273, 27364-27373 (1998)
  • Reverse Biochemistry: Use of Macromolecular Protease Inhibitors To Dissect Complex Biological Processes and Identify a Membrane-Type Serine Protease in Epithelial Cancer and Normal Tissue. T. Takeuchi, M.A. Shuman & C.S. Craik. Proc. Natl. Acad. Sci 96, 11054-11061 (1999)
  • Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries. J.L. Harris, B.J. Backes, F. Leonetti, S. Mahrus, J.A. Ellman and C.S. Craik. Proc. Natl. Acad. Sci., 275, 7754-59 (2000)
  • The Structure of the Pro-apoptotic Protease Granzyme B Reveals the Molecular Determinants of its Specificity. S. Waugh, J. Harris, R. Fletterick, and C.S. Craik Nature Structural Biology 7, 762-765 (2000)
  • Characterization of Structural Determinants of Granzyme B Reveals Potent Mediators of Extended Substrate Specificity. Ruggles SW, Fletterick RJ and Craik CS J. Biol. Chem 279, 30751-30759, (2004).
Edwin L. Madison, PhD
  • "Engineering factor VIIa molecules with improved therapeutic properties for treatment of patients with inhibitors" Madison, E.L., DeLuca-Flaherty, C., Erbe, D., McCluskie, K., Blouse, G. and Thanos, C., Haemophilia 16 (Suppl 4), 75 (2010).
  • "Serpin-resistant Mutants of Human Tissue-type Plasminogen Activator" Madison, E.L., Goldsmith, E.J., Gerard, R.D., Gething, M.J., and Sambrook, J. Nature 339, 721-23 (1989).
  • "Amino acid residues that affect interaction of tissue type plasminogen activator with plasminogen activator inhibitor type 1". Madison, E.L., Goldsmith E.J., Gerard, R.D.,, Gething, M.J., Sambrook, J, and Bassel-Duby, R.S. Proc. National Academy Sciences USA 87, 3530-3533 (1990)
  • "Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser" Madison, E.L., Gething, M.J., Sambrook, J.F., and Goldsmith, E.J. Science 262, 419 ã 421 (1993).
  • "Inhibitor-Resistant Tissue Type Plasminogen Activator: An Improved Thrombolytic Agent" Shohet, R.V., Spitzer, S., Madison, E.L., Bassel-Duby, R., Gething, M. J., and Sambrook, J.F. Thrombosis and Hemostasis 71, 124-128 (1994).
  • "Substrate Specificity of Tissue Type Plasminogen Activator" Madison, E.L., Coombs, G., and Corey, D., J. Biol. Chem. 270, 7558-7562 (1995).
  • "Variants of Tissue Type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator, Type 1" Tachias, K. and Madison, E. L., J. Biol. Chem. 272, 14580-14585 (1997).
  • "Optimal Subsite Occupancy and Design of a Selective Inhibitor for Urokinase" Ke, S., Coombs, G., Corey, D., and Madison, E.L., J. Biol. Chem. 272, 20456 ã 20462 (1997).
  • "Targeting Sequence Specific Proteolysis to Nonphysiological Protein Substrates. The Influence of Loop Size and Target Sequence on Selective Proteolysis by Tissue Type Plasminogen Activator and Urokinase Type Plasminogen Activator² Coombs, G.S., Bergstrom, R.C., Madison, E.L., Corey, D.R., J. Biol. Chem. 273, 4323 ã 4328 (1998).
  • "Substrate Specificity of Prostate Specific Antigen (PSA)" Coombs, G.S., Bergstrom, R.C., Pellequer, J.L., Baker, S.I., Navre, M., Smith, M.M., Tainer, J.A., Madison, E.L., and Corey, D.R., Chemistry and Biology 5, 475-488 (1998).
  • "Distinct Contributions of Residue 192 to the Specificity of Coagulation and Fibrinolytic Serine Proteases" Zhang, Y.L., Hervio, L., Strandberg, L., and Madison, E.L. J. Biol. Chem. 274, 7153-7156 (1999).
  • "Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Mainchains" Coombs, G.S., Rao, M.S., Olson, A.J., Dawson, P.E., and Madison, E.L. J. Biol. Chem. 274, 24074-24079 (1999).
  • "Catalytic domain structure of MTSP-1/matriptase, a matrix-degrading transmembrane serine proteinase" Rainer F, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W and Madison E, J Biol. Chem. 277, 2160-2168 (2002).
  • "Binding of nonphysiological protein and peptide substrates to proteases: difference between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis," Bergstrom RC, Coombs GS, Ye S, Madison EL, Goldsmith EJ, Corey DR, Biochemistry, 42, 5395-402 (2003).