Job Title:
Scientist, Protein Sciences
Job Code:
MF10-120
Catalyst Overview
Founded in 2003, Catalyst Biosciences, Inc. is a leading biotechnology company focused on developing proteases as a therapeutic platform for hemophilia, age-related macular degeneration, oncology and inflammation. Proteases are well established as a class of drugs, with over 7 protease drugs on the market and over $3.5 billion in annual sales. Catalyst is developing and intends to market both natural and engineered human proteases ("Alterase™ therapeutics") to treat major diseases. By engineering human proteases to alter their substrate specificity so that they can inactivate any given protein target, Catalyst will vastly increase the use and application for therapeutic proteases, and create a new paradigm in target intervention. Catalyst has assembled a team of world-class scientists and advisors, an enabling technology platform, and a robust pipeline, and is thus poised to become a fully integrated biopharmaceutical company with a diversified portfolio.
Summary of the Position
The Scientist will report to a Senior Scientist, in the Protein Sciences and Fermentation group. As a member of this group, the incumbent will participate in the expression of pre-clinical candidate proteins for in-vitro and in-vivo screening leading to the selection of a candidate for clinical testing. This position will involve participating in production of candidate therapeutic proteins, the optimization of processes for small scale bioreactors, participating in growing and manipulating CHO host cells and recombinant CHO cell lines in a serum-free suspension culture. The work scope will also involve manipulating and preparing expression vector plasmids using molecular biology techniques including RT-PCR, and engineering CHO cell lines to overcome bottlenecks.
Requirements
PhD in Cell Biology or other relevant field with minimum of 3 years Post-Doctoral experience
Excellent aseptic technique
Ability to perform work in a careful and meticulous manner
Ability to lift and push up to 30lbs.
Willingness to learn and take initiative
Preference will be given to candidates with:
Industrial experience
Experience growing cells at large scale
Flexibility to work evening and/or weekend hours
If you would like to apply for this position, please send your CV/resume to jobs@catbio.com and include the job title and code in the subject line of your email.